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双药抗艾方案三期临床结果不逊于三药方案

葛兰素史克DTG双药方案大获成功,三期临床结果不劣于三药方案   ViiV Healthcare的Tivicay和Epivir的两种药物HIV方案在试验中取得成功,显示出不劣于三药方案,因此有可能为患者提供另一种治疗方案。   III期临床研究GEMINI-1和GEMINI-2研究评估了Tivicay(多替拉韦钠,dolutegravir)和Epivir(拉米夫定)与Tivicay和两种核苷逆转录酶抑制剂替诺福韦/恩曲他滨(TDF/FTC, Truvada)。   这项研究涉及基线病毒载量低于500000 copies/ml的未经治疗的HIV-1成人感染者,在第48周基于血浆HIV-1 RNA <50拷贝/ml的非劣效性作为其衡量病毒控制标准的治疗注意终点。   ViiV强调,2DR的安全性数据也与药物的产品标签一致,并且任何一个治疗组出现病毒学失败的患者均未出现治疗应急性耐药。   “在目前的护理标准下,许多患者每天仍然服用三种或更多种药物。GEMINI研究证明了dolutegravir加拉米夫定双药联合的效果,安全性和耐受性。”ViiV首席科学和医学官员John Pottage说。   “研究肯定了我们的双药方案策略,并强化了我们的信念,即许多患者可以用两种药物而不是三种或更多来控制他们的疾病。重要的是,这些研究表明,这种双药方案可以成为治疗初治患者的一种选择,并且可以支持世界各地广泛的艾滋病病毒感染患者。”   研究的全部数据将在即将召开的科学会议上提出,据报道该公司正在寻求在今年晚些时候提交双药方案。   同时有消息称,美国食品和药物管理局在发现“小缺陷”后,拒绝其竞争对手Mylan申请仿制葛兰素史克的重磅哮喘药物Advair的仿制药。该公司没有提供进一步的细节,不清楚该公司是否能够解决,并在今年获得批准。   (来源:有一点进展)
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Helix Studios - What About Your Roommate Jessie Montgomery, Kody Knight, Tyler Hill.mp4

If you live with a roommate, you’ve probably memorized his daily schedule. You know exactly what times he’ll be gone, giving you free reign of the apartment to do whatever you want, and make as much noise as you want with whomever you want. Not expecting his roommate Kody to return for a few more hours, Jessie invites Tyler over for a midday hookup. The horny boys strip down to nothing but perfect bodies, not even bothering to close the bedroom door. But today, Kody comes home early to find Tyler working his warm mouth over Jessie’s big, hard dick, and he’s way too turned on to be angry. Instead, Kody starts stoking his own big cock. Once Jessie notices his roommate standing in the doorway, jerking off to the sight of his dick stuffed between Tyler’s perfectly round ass cheeks, he invites Kody to join, and this party of two grows into a full-scale three-way.
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CockyBoys - Damian Rios fucks Tori Andrews.wmv

Damian Rios Fucks Twinkie Tori
Requested
Sometimes a guy's just in the mood to see a hot blonde twink get drilled and that's exactly the mood I was in when I picked up Damian and Tori at the bar one night. I saw them flirting with each other by the dance floor, walked up to them and told them if they were gonna go home to fuck that they may as well do it on camera for me and make some money in the process...and they agreed! You gotta love the power of alcohol. They start off making out in bed but it isn't long before Tori is gobbling up Damian's cock. Once Damian's nice and hard he flips Tori over so he can tongue lash that sweet hole of his to get it all wet and ready. Tori, clearly a talented bottom, puts a condom between his teeth and actually rolls it on to Damian's eager cock with his mouth. Then he climbs on top of Damian and rides that dick for all it's worth. Damian flips Tori over onto his back so he can fuck his hot ass while the two make out furio…

MaleSpectrum - Desperate Twinks 2

Hi there little twink... can't pay the rent? Missed a car payment? Need some money for a fierce new pair of cowboy boots? Well Male Spectrum has an offer you can't refuse! That's right, Male Spectrum has done it again, delivering a new digest of despondent dick-suckers in Desperate Twinks Vol. 2! These taut twiggy twinks are ready and willing to get their mouths manhandled and their pregnable assholes parted and pounded by behemothic boners all in the name of cold, hard cash!
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[Icon Male] A Southern Boys Charm - Kory Houston Michael Delray

Tutor succumbs to a southern boy's charm.
​Handsome actors from Mormonboyz, YoungPerps, FamilyDick.
​720p mp4.
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“不一样的烟火”,一样可以绽放

谈到“性”,不少人会觉得难以启齿。然而,孩子们总爱问“我是从哪里来的”,很多家长只好选择搪塞其词。不过,一段时间以来,一套名为《珍爱生命——小学生性健康教育读本》的教材,消除了家长和老师在给孩子们解说性时的尴尬。这套依据联合国教科文组织《国际性教育技术指导纲要》编写而成的性教育读本,从最初被视为“大尺度”到现在越来越受欢迎,背后的原因,网友一言以蔽之——“三观正”。 这套读本的“三观正”,从一个例子可见一斑。在六年级上册中,专门有一个单元讲述“性别与权利”,其中介绍了不同的性倾向。这本教材说,性倾向不止一种,不管是同性恋还是双性恋都属正常,绝不是疾病。
​的确,这应该是一个共识,同性恋绝非一种精神疾病。早在1990年,世界卫生组织就正式将同性恋从疾病名册中去除;2001年,中华精神科学会也将同性恋从精神疾病分类中删除。不歧视同性恋,并且保障其权益,更是现代社会的基本原则。正如这本教材中所说的,每一个人都是独一无二的,长相、肤色、身高、体重、性格、民族、国籍都不相同,性倾向只是不同的一个方面。
不过,这样能写入孩子们教材的认识,也并非自然而然形成的。对不同性倾向的尊重与保护,在一定程度上体现着社会的文明程度。这可以从两个方面理解。一方面是个体的权利。性倾向,在本质上是一种个人权利,只要不妨碍他人,每个人都有选择自己生活方式的自由。另一方面,则是少数群体的权利。同性恋者在性倾向上是少数群体,保护少数人的权利,也是社会公平正义的必然。从情感上,各人对同性恋的接受度可以不同;但是从理智上,尊重他人的性倾向却应该是共识。
​消除偏见,理解差异,应是社会的信念,我们都可以从这套小学教材中学到更多。或许,我们可以更多地学会理解“不一样的烟火”。罗素曾言,“须知参差多态,乃是世界本源”。在很大程度上,同性恋的存在,也正是人类在性意识、性倾向上“参差多态”的体现。从《荷马史诗》中英雄阿喀琉斯和同伴的情谊,到托马斯·曼名著《魂断威尼斯》中对同性之美的热烈赞叹,许多文艺作品在探索人类心灵的过程中触及同性恋的主题,更让人看到,人类最宝贵的情感,本就是在性别界限之上的。
​当然,如果涉及违法犯罪,不管是同性恋还是异性恋,都应该受到法律制裁,这同样是一个基本原则。正如网络上的不少内容,如果涉黄涉暴、违法违规,不管是哪种性倾向的内容,都应该坚决清理。网络泥沙俱下让人忧心,不过在处理时也需要把握…